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KMID : 0644120160290020001
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Journal of Oriental Gynecology
2016 Volume.29 No. 2 p.1 ~ p.14
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Effects of Dokwhalgisaeng-tang Gamibang (DGG) Water Extract on Dexamethasone-treated Osteoblast
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Baek Seon-Eun
Jang Sae-Byul
Yoo Jeong-Eun
Yoo Dong-Youl
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Abstract
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Objectives: In this study, the author aimed to evaluate the effects of water extract of Dokwhalgisaeng-tang Gamibang (DGG) on osteoblast proliferation in murine calvarial cells.
Methods: The osteoblast separated from murine calvariae was cultivated and evaluated the cell function. After the addition of DGG on the culture medium, we determined the effect of DGG on the cell proliferation, protein synthesis, alkaline phosphatase activity, collagen synthesis, and cell viability of the cultivated osteoblast in the presence of dexamethasone.
Results: DGG increased the survival rate, proliferation, alkaline phosphatase (ALP) activity, protein synthesis and collagen synthesis of rat calvarial osteoblast in the presence of dexamethasone.
Conclusions: DGG might improve the osteoporosis resulted from augmentation of osteoblast proliferation.
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KEYWORD
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Dokwhalgisaeng-tang Gamibang (DGG), osteoporosis, osteoblast, osteoblastogenesis
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